Port Glasgow railway station is on the Inverclyde Line, serving the town of Port Glasgow, Scotland. It is located in the town centre with the main entrance at the junction of Princes Street and John Wood Street.

It opened on 31 March 1841, being one of the intermediate stations on the Glasgow, Paisley and Greenock Railway which opened on that date. It later became a junction in 1865, when the branch to Wemyss Bay was opened. The main line was then extended to Gourock in 1889 by the Caledonian Railway.

The two lines diverge to the west of the station, with the Wemyss Bay branch now mostly single track all the way to the terminus; the Gourock line is double throughout. Both lines were electrified in 1967 by British Rail using the 25 kV AC system, with the branch partially singled as part of the modernisation work. A (now disused) connection to the former Glasgow and South Western Railway station at Greenock diverged from the branch line a short distance west of the junction. The old station was used for a period (circa 1971–84) as a container terminal but was officially closed in September 1991.

There was a bay platform at the west end of the station for services to Wemyss Bay. The platform was located on the south side of the line and is now infilled – prior to electrification, it was used for carriages which were added to (and on return detached from) Wemyss Bay trains.