Hairmyres railway station is a railway station in the Hairmyres area of East Kilbride, South Lanarkshire, Greater Glasgow, Scotland. The station is managed by ScotRail and is on the Glasgow South Western Line 10 miles (16 km) southeast of Glasgow Central towards East Kilbride.

The line is single here with a passing loop approximately 398 metres (435 yd) east of Hairmyres Station, which extends for approximately 584 metres (639 yd) to Kirktonholme Road East Kilbride. It is crossed mid-loop by the A726 Queensway overbridge. Although the line was always single between Busby and East Kilbride, sidings existed to serve the former Radio Times factory in the College Milton Industrial Estate adjacent to the station. These were closed and lifted in the late 1960s. The Hairmyres Hospital and Department for International Development's office are located nearby.

Up until the mid-1990s the area around the station was semi rural, but several new housing schemes have been built up in the area over the last decade or so giving far increased patronage to the station.

In the 2020s, plans were advanced to rebuild the station 600m to the west of its original location. As of 2024, the new station is under construction.