Berwick-upon-Tweed is a railway station on the East Coast Main Line, which runs between London King's Cross and Edinburgh Waverley. The station, situated 67 miles (108 km) north-west of Newcastle, serves the border town of Berwick-upon-Tweed in Northumberland, England. It is owned by Network Rail and managed by London North Eastern Railway.

It is the most northerly railway station in England, being less than 3 miles (4.8 km) from the border with Scotland. The station, with its long single island platform, lies immediately to the north of the Royal Border Bridge.